A selective and reversible inhibitor of IKK2 (IC50 = 3- 12 μM) that displays >10-fold selectivity over 28 other kinases; attenuates NF-κB-mediated gene expression in synovial fibroblasts

SC-514 – 5 mg

Brand:
Cayman
CAS:
354812-17-2
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

SC-514 is a selective and reversible inhibitor of IκB kinase 2 (IKK2) (IC50 = 3-12 μM) that displays greater than 10-fold selectivity over 28 other kinases, including JNK, p38, MK2, and ERK.{17344,17345} In synovial fibroblasts stimulated with interleukin (IL)-1β, SC-514 attenuates NF-κB-mediated expression of IL-6, IL-8, and cyclooxygenase-2 (IC50s = 20, 20, and 8 μM, respectively).{17344} SC-514 also reduces NF-κB-mediated expression of other genes, including iNOS in LPS-stimulated smooth muscle cells{17346} and TLR2 in TNF-activated astrocytes.{17347}  

 

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SKU: 10010267 - 5 mg Category:

Description

A selective and reversible inhibitor of IKK2 (IC50 = 3- 12 μM) that displays >10-fold selectivity over 28 other kinases; attenuates NF-κB-mediated gene expression in synovial fibroblasts, smooth muscle cells, and astrocytes

Formal name: 4-amino-[2,3′-bithiophene]-5-carboxamide

Synonyms: 

Molecular weight: 224.3

CAS: 354812-17-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|IKKs||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|STING||Research Area|Infectious Disease

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