A selective EP1 antagonist that displays analgesic activity in mice (ED50 = 6.3 mg/kg when given subcutaneously) and in rats; inhibits the growth of glioma cell lines in vitro (IC50 = ~1 μM) and slows tumor growth in vivo; attenuates neuronal cell death in response to oxidative stress

SC-51089 – 1 mg

Brand:
Cayman
CAS:
146033-02-5
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

The prostaglandin E2 (PGE2) receptor EP1 is involved in triggering PGE2-mediated pain as well as neuronal survival and growth. SC-51089 is a selective EP1 antagonist, first shown to have in vivo analgesic activity in mice (ED50 = 6.3 mg/kg when given subcutaneously) and in the rat.{17835,17836} SC-51089 also inhibits the growth of glioma cell lines in vitro (IC50 = ~1 μM) and slows tumor growth in vivo.{17837} In addition, SC-51089 is neuroprotective, attenuating neuronal cell death in response to oxidative stress, an effect that is also found in EP1-/- mice and mediated by PGE2.{15975,17838}  

 

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SKU: 10011561 - 1 mg Category:

Description

A selective EP1 antagonist that displays analgesic activity in mice (ED50 = 6.3 mg/kg when given subcutaneously) and in rats; inhibits the growth of glioma cell lines in vitro (IC50 = ~1 μM) and slows tumor growth in vivo; attenuates neuronal cell death in response to oxidative stress

Formal name: 8-chloro-2-[1-oxo-3-(4-pyridinyl)propyl]hydrazide-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, monohydrochloride

Synonyms:  CID132748

Molecular weight: 459.3

CAS: 146033-02-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cancer||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Neuroscience|Pain Research

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