A selective inhibitor of Δ6 desaturase (IC50 = 0.2 µM in a rat liver microsomal assay) that completely blocks the conversion of linoleic acid to AA; orally active in vivo

SC 26196 – 1 mg

Brand:
Cayman
CAS:
218136-59-5
Storage:
-20
UN-No:
Non-Hazardous - /

The enzyme Δ6 desaturase mediates the conversion of linoleic acid to γ-linolenic acid (GLA), which can then be elongated to dihomo-γ-linolenic acid (DGLA). DGLA can then be used as a substrate for Δ5 desaturase to produce arachidonic acid (AA), the fatty acid that is used to generate eicosanoids. SC 26196 is an inhibitor of Δ6 desaturase (IC50 = 0.2 µM in a rat liver microsomal assay) that completely blocks the conversion of linoleic acid to arachidonic acid (AA).{29588} It is selective for Δ6 desaturase, as IC50 values for Δ5 and Δ9 desaturases exceed 200 µM and it has no effect on the conversion of dihomo-γ-linolenic acid to AA.{29588,29586} SC 26196 is orally active in vivo, decreasing edema in the carrageenan paw edema model in mice.{29588} It also blocks aging-related increases in AA in myocardial cardiolipin in mice, attenuating contractile dysfunction without impacting mitochondrial oxidative stress.{29587}  

 

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SKU: 10792 - 1 mg Category:

Description

A selective inhibitor of Δ6 desaturase (IC50 = 0.2 µM in a rat liver microsomal assay) that completely blocks the conversion of linoleic acid to AA; orally active in vivo, decreasing edema in the carrageenan paw edema model in mice,

Formal name: α,α-diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile

Synonyms:  α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile

Molecular weight: 423.6

CAS: 218136-59-5

Purity: ≥98%

Formulation:

Product Type|Biochemicals|Small Molecule Inhibitors|Fatty Acid Metabolism||Research Area|Immunology & Inflammation||Research Area|Lipid Biochemistry|Fatty Acids|Synthesis

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