A potent

SC-236 – 50 mg

Brand:
Cayman
CAS:
170569-86-5
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

The physiologic roles and importance of constitutive COX-1 and inducible COX-2 have been reviewed.{11295,10878} SC-236 is a potent, selective, orally active inhibitor of COX-2 with an IC50 of 10 nM and approximately 18,000-fold COX-2 selectivity.{12282} SC-236 has a long plasma half-life and can be dosed once daily (20 mg/kg) in rodents to achieve lasting inhibition of COX-2.{11450}  

 

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SKU: 10004219 - 50 mg Category:

Description

A potent, selective, orally active inhibitor of COX-2 with an IC50 value of 10 nM and approximately 18,000-fold selectivity for COX-2 over COX-1

Formal name: 4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide

Synonyms: 

Molecular weight: 401.8

CAS: 170569-86-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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