A modulator of PCSK9 action that blocks LDLR degradation

SBC-115076 – 1 mg

Brand:
Cayman
CAS:
489415-96-5
Storage:
-20
UN-No:
Non-Hazardous - /

Proprotein convertase subtilisin kexin 9 (PCSK9) is a member of the subtilisin serine protease family with important roles in lipoprotein metabolism.{13178} PCSK9 overexpression in wild-type mice doubles plasma total cholesterol, possibly through acceleration of degradation of the LDL receptor (LDLR).{13178,13176} SBC-115076 is an inhibitor of PCSK9 action that blocks LDLR degradation in HEK293T cells expressing PCSK9.{30917} Through this mechanism, submicromolar concentrations of SBC-115076 increase the uptake of LDL by liver cells in vitro.{30917} SBC-115076 is effective in vivo, lowering cholesterol levels in mice that are fed a high fat diet.{30917}  

 

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Description

A modulator of PCSK9 action that blocks LDLR degradation, increasing the uptake of LDL by liver cells in vitro; lowers cholesterol levels in mice that are fed a high fat diet

Formal name: 1,5-dihydro-3-hydroxy-4-[3-methyl-4-(phenylmethoxy)benzoyl]-1-[3-(4-morpholinyl)propyl]-5-(4-pyridinyl)-2H-pyrrol-2-one

Synonyms: 

Molecular weight: 527.6

CAS: 489415-96-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins

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