A PCSK9 inhibitor; increases LDLR levels in HepG2 cells expressing PCSK9 at 400 nM; reduces plasma total cholesterol levels by a mean of 38% in mice fed a high-fat diet at 8 mg/kg per day; reduces plasma LDL cholesterol levels in mice fed a high-fat diet and exhibits an additive effect when administered in combination with atorvastatin

SBC-110736 – 10 mg

Brand:
Cayman
CAS:
1629166-02-4
Storage:
-20
UN-No:
Non-Hazardous - /

SBC-110736 is an inhibitor of proprotein convertase subtilisin kexin type 9 (PCSK9).{53726} It increases LDL receptor (LDLR) levels in HepG2 cells expressing PCSK9 when used at a concentration of 400 nM. SBC-110736 (8 mg/kg per day) reduces plasma total cholesterol levels by a mean of 38% in mice fed a high-fat diet. It also reduces plasma LDL cholesterol levels in mice fed a high-fat diet and exhibits an additive effect when administered in combination with atorvastatin (Item No. 10493).  

 

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SKU: 23103 - 10 mg Category:

Description

A PCSK9 inhibitor; increases LDLR levels in HepG2 cells expressing PCSK9 at 400 nM; reduces plasma total cholesterol levels by a mean of 38% in mice fed a high-fat diet at 8 mg/kg per day; reduces plasma LDL cholesterol levels in mice fed a high-fat diet and exhibits an additive effect when administered in combination with atorvastatin,,

Formal name: N-[4-[[4-(4-methylphenyl)-2-phenyl-1-piperazinyl]carbonyl]phenyl]-acetamide

Synonyms: 

Molecular weight: 413.5

CAS: 1629166-02-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cardiovascular System|Lipids & Lipoproteins||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias

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