A TGR5 agonist (EC50 = 1.3 μM for the human receptor); selective for TGR5 over FXR and panel of other receptors

SB-756050 – 10 mg

Brand:
Cayman
CAS:
447410-57-3
Storage:
-20
UN-No:
Non-Hazardous - /

SB-756050 is an agonist of the bile acid G protein-coupled receptor TGR5 (EC50 = 1.3 μM for the human receptor).{45338} It is selective for TGR5 over the farnesoid X receptor (FXR) and a panel of other receptors, channels, and transporters. SB-756050 (10-100 mg/kg) decreases fasting glucose levels and increases glucose disposal rate and insulin secretion in diabetic Goto Kakizaki rats.  

 

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SKU: 27998 - 10 mg Category:

Description

A TGR5 agonist (EC50 = 1.3 μM for the human receptor); selective for TGR5 over FXR and panel of other receptors, channels, and transporters; decreases fasting glucose levels and increases glucose disposal rate and insulin secretion in diabetic Goto Kakizaki rats from 10-100 mg/kg

Formal name: 1,4-bis[(3,4-dimethoxyphenyl)sulfonyl]hexahydro-1H-1,4-diazepine

Synonyms: 

Molecular weight: 500.6

CAS: 447410-57-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Bile Acids & Microbiome||Research Area|Endocrinology & Metabolism|Hormones & Receptors||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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