A potent and selective non-peptide OX1R antagonist (Kd = 5.03 and 3.76 nM in whole cell binding and membrane-based assays

SB-674042 – 1 mg

Brand:
Cayman
CAS:
483313-22-0
Storage:
-20
UN-No:
Non-Hazardous - /

SB-674042 is a potent and selective non-peptide orexin 1 receptor (OX1R) antagonist (Kd = 5.03 and 3.76 nM in whole cell binding and membrane-based assays, respectively).{34091} In calcium mobilization studies, it was >100-fold selective for OX1 over OX2 and did not show significant affinity for serotonergic, dopaminergic, adrenergic, or purinergic receptors at concentrations up to 10 µM.{34090}  

 

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Description

A potent and selective non-peptide OX1R antagonist (Kd = 5.03 and 3.76 nM in whole cell binding and membrane-based assays, respectively); >100-fold selective for OX1 over OX2 in calcium mobilization; no significant affinity for serotonergic, dopaminergic, adrenergic, or purinergic receptors

Formal name: [5-(2-fluorophenyl)-2-methyl-4-thiazolyl][(2S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]-1-pyrrolidinyl]-methanone

Synonyms: 

Molecular weight: 448.5

CAS: 483313-22-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience

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