A selective

SB-3CT – 1 mg

Brand:
Cayman
CAS:
292605-14-2
Storage:
-20
UN-No:
Non-Hazardous - /

SB-3CT is a selective, mechanism-based inhibitor of the gelatinases, matrix metalloproteinase-2 (MMP-2) and MMP-9 (Kis = 28 and 400 nM, respectively).{26759,26757} First pass metabolism of SB-3CT in vivo produces a monohydroxylated metabolite that has greater inhibitory activity (Kis = 6 and 160 nM for MMP-2 and MMP-9, respectively).{26757} Both SB-3CT and its active metabolite can cross the blood-brain barrier and have utility in diseases of the central nervous system, such as stroke and traumatic brain injury.{26757,26758} SB-3CT may have applications in other pathologies involving gelatinases, including cancer, cardiovascular diseases, and inflammation.{26760,26756}  

 

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Description

A selective, mechanism-based inhibitor of MMP-2 and MMP-9 (Kis = 28 and 400 nM, respectively); a monohydroxylated metabolite has greater inhibitory activity (Kis = 6 and 160 nM for MMP-2 and MMP-9, respectively); can cross the blood-brain barrier

Formal name: 2-[[(4-phenoxyphenyl)sulfonyl]methyl]-thiirane

Synonyms:  Matrix Metalloproteinase-2/9 Inhibitor IV|MMP-2/MMP-9 Inhibitor IV

Molecular weight: 306.4

CAS: 292605-14-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Cardiovascular System|Cardiovascular Diseases|Stroke

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