A selective TRPV1 antagonist widely used in pain research; inhibits capsaicin-evoked Ca2+ influx with an IC50 value of 0.7 μM in cultured trigeminal ganglion neurons; reduces capsaisin-induced nociceptive responses in a model of pain and suppresses tolerance to the analgesic effects of chronic morphine administration in rats

SB-366791 – 50 mg

Brand:
Cayman
CAS:
472981-92-3
Storage:
-20
UN-No:
Non-Hazardous - /

The transient receptor potential vanilloid type 1 (TRPV1) receptor is a nonselective cation channel gated by noxious heat, protons, and capsaicin. TRPV1 is present in primary sensory neurons and in both central and peripheral sensory nerve terminals and plays a role in thermal and mechanical hyperalgesia. SB-366791 is a selective TRPV1 antagonist that is widely used in pain research.{20043} In cultured trigeminal ganglion neurons, SB-366791 inhibits capsaicin-evoked Ca2+ influx with an IC50 value of 0.7 μM.{20043} A 1 nmol injection of SB-366791 in mouse paw reduces capsaicin-induced nociceptive responses in a model of pain.{20044} Intrathecal pretreatment of 10 μl SB-366791 in rats suppresses tolerance to the analgesic effects of chronic morphine administration.{20045} Co-administration of morphine and SB-366791 at 0.1 mg/kg has potent analgesic effects in a mouse model of bone cancer pain.{20046}  

 

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SKU: 11019 - 50 mg Category:

Description

A selective TRPV1 antagonist widely used in pain research; inhibits capsaicin-evoked Ca2+ influx with an IC50 value of 0.7 μM in cultured trigeminal ganglion neurons; reduces capsaisin-induced nociceptive responses in a model of pain and suppresses tolerance to the analgesic effects of chronic morphine administration in rats

Formal name: 3-(4-chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide

Synonyms: 

Molecular weight: 287.7

CAS: 472981-92-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Neuroscience|Pain Research

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