An OX1R antagonist (KB = 39.8 nM); selective for OX1R over OX2R (KB = 1

SB-334867 – 5 mg

Brand:
Cayman
CAS:
792173-99-0
Storage:
-20
UN-No:
Non-Hazardous - /

SB-334867 is an antagonist of the orexin 1 receptor (OX1R; KB = 39.8 nM) that is selective for OX1R over OX2R (KB = 1,995.3 nM).{43606} It reduces food intake and increases resting duration in rats, as well as inhibits orexin-A-induced increases in food intake, when administered at a dose of 30 mg/kg.{43607} SB-334867 (10 mg/kg) inhibits orexin-A-induced increases in grooming time in rats.{43606} It increases the seizure threshold in both the maximal electroshock seizure threshold (MEST) and 6 Hz psychomotor seizure test in mice when administered at doses of 30 and 3 mg/kg, respectively.{43608} Intracerebroventricular administration of SB-334867 (0.5-50 nmol) reduces morphine-induced analgesia in the formalin test in rats.{43609} SB-334867 (1.5 to 6 μg, intra-dentate gyrus injection) also reduces acquisition and consolidation of spatial memory in the Morris water maze in rats.{43610}  

 

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Description

An OX1R antagonist (KB = 39.8 nM); selective for OX1R over OX2R (KB = 1,995.3 nM); reduces food intake and increases resting duration in rats, as well as inhibits orexin-A-induced increases in food intake, at 30 mg/kg; inhibits orexin-A-induced increases in grooming time in rats at 10 mg/kg; increases the seizure threshold in both the MEST and 6 Hz psychomotor seizure test in mice at 30 and 3 mg/kg, respectively; reduces morphine-induced analgesia in the formalin test in rats at 0.5-50 nmol, i.c.v.; reduces acquisition and consolidation of spatial memory in the Morris water maze in rats when administered to the dentate gyrus at 1.5-6 μg,

Formal name: N-(2-methyl-6-benzoxazolyl)-N’-1,5-naphthyridin-4-yl-urea

Synonyms: 

Molecular weight: 319.3

CAS: 792173-99-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Behavioral Neuroscience|Food Intake||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Pain Research||Research Area|Neuroscience|Seizure Disorders

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