Description
An OX1R antagonist (KB = 39.8 nM); selective for OX1R over OX2R (KB = 1,995.3 nM); reduces food intake and increases resting duration in rats, as well as inhibits orexin-A-induced increases in food intake, at 30 mg/kg; inhibits orexin-A-induced increases in grooming time in rats at 10 mg/kg; increases the seizure threshold in both the MEST and 6 Hz psychomotor seizure test in mice at 30 and 3 mg/kg, respectively; reduces morphine-induced analgesia in the formalin test in rats at 0.5-50 nmol, i.c.v.; reduces acquisition and consolidation of spatial memory in the Morris water maze in rats when administered to the dentate gyrus at 1.5-6 μg,
Formal name: N-(2-methyl-6-benzoxazolyl)-N’-1,5-naphthyridin-4-yl-urea
Synonyms:
Molecular weight: 319.3
CAS: 792173-99-0
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Behavioral Neuroscience|Food Intake||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Pain Research||Research Area|Neuroscience|Seizure Disorders
