A selective antagonist of CCR3 (IC50 = 39 nM); suppresses antigen-induced accumulation of Th2 lymphocytes and eosinophils in lungs of mice when delivered subcutaneously

SB 297006 – 1 mg

Brand:
Cayman
CAS:
58816-69-6
Storage:
-20
UN-No:
De Minimis - 3077 / 9

SB 297006 is an antagonist of C-C chemokine receptor 3 (CCR3; IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ.{32621} It is at least 250-fold selective for CCR3 over a panel of other chemokine receptors. SB 297006 blocks CCR3-mediated calcium mobilization induced by eotaxin, eotaxin-2, and MCP-4 in transfected cells.{32621} It suppresses antigen-induced accumulation of Th2 lymphocytes and eosinophils in lungs of mice when delivered subcutaneously (100 mg/kg).{32620}  

 

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SKU: 11964 - 1 mg Category:

Description

A selective antagonist of CCR3 (IC50 = 39 nM); suppresses antigen-induced accumulation of Th2 lymphocytes and eosinophils in lungs of mice when delivered subcutaneously

Formal name: N-benzoyl-4-nitro-L-phenylalanine, ethyl ester

Synonyms: 

Molecular weight: 342.4

CAS: 58816-69-6

Purity: ≥99%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Innate Immunity

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