A selective antagonist of the dopamine D3 receptor (pKi = 8.0); has high oral bioavailability and enters the central nervous system of the rat

SB 277011A (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
1226917-67-4
Storage:
-20
UN-No:
Non-Hazardous - /

SB 277011A is an antagonist of the dopamine D3 receptor (pKi = 8.0) that is at least 100-fold selective for D3 over other monoamine receptors (pKis = 6.0, 5.0, and 2, 5-HT1D and 5-HT1B respectively).{31910,31909,31908} It has high oral bioavailability and enters the central nervous system of the rat.{31910} SB 277011A has been shown to have potential benefits in animal models of schizophrenia and Parkinson’s disease.{31909,31907}  

 

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SKU: 11982 - 5 mg Category:

Description

A selective antagonist of the dopamine D3 receptor (pKi = 8.0); has high oral bioavailability and enters the central nervous system of the rat

Formal name: N-[trans-4-[2-(6-cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide, dihydrochloride

Synonyms: 

Molecular weight: 511.5

CAS: 1226917-67-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease

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