A selective

SB-271046 (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
209481-24-3
Storage:
-20
UN-No:
Non-Hazardous - /

SB-271046 is an orally-available antagonist of the serotonin (5-hydroxytryptamine, or 5-HT; Item No. 14332) receptor 5-HT6 (pKi = 9.02-8.92).{29779,29781} It is at least 100-fold selective for 5-HT6 over other 5-HT receptors, as well as 55 other receptors, enzymes, and ion channels.{29781} While it does not alter basal levels of 5-HT, dopamine, or noradrenaline, SB-271046 produces a significant increase in extracellular levels of glutamate and aspartate within the frontal cortex.{29780} It has been used to evaluate the role of 5-HT6 in learning and memory.{29782}  

 

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Description

A selective, orally-available antagonist of the 5-HT6 receptor (pKi = 9.02-8.92); produces a significant increase in extracellular levels of glutamate and aspartate within the frontal cortex; used to evaluate the role of 5-HT6 in learning and memory

Formal name: 5-chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methyl-benzo[b]thiophene-2-sulfonamide, monohydrochloride

Synonyms: 

Molecular weight: 488.4

CAS: 209481-24-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis

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