A selective p38 MAP kinase inhibitor (IC50 = 44 nM for p38α) that has been shown to reduce inflammatory cytokine production and is neuroprotective following oral administration in vivo

SB 239063 – 5 mg

Brand:
Cayman
CAS:
193551-21-2
Storage:
-20
UN-No:
Non-Hazardous - /

SB 239063 is a selective p38 MAPK inhibitor (IC50 = 44 nM for recombinant purified p38α).{30980} It displays greater than 220-fold selectivity for p38 MAPK over ERK, JNK1, and other kinases.{30980} SB 239063 has been shown to reduce inflammatory cytokine production in lipopolysaccharide-stimulated human peripheral blood monocytes (IC50s = 0.12 and 0.35 µM, respectively for IL-1 and TNF-α) and is neuroprotective following oral administration in a rat model of cerebral focal ischemia.{30980,30979}  

 

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Description

A selective p38 MAP kinase inhibitor (IC50 = 44 nM for p38α) that has been shown to reduce inflammatory cytokine production and is neuroprotective following oral administration in vivo

Formal name: trans-4-[4-(4-fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl]-cyclohexanol

Synonyms: 

Molecular weight: 368.4

CAS: 193551-21-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|p38 MAPK||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|p38 MAPK Signaling||Research Area|Immunology & Inflammation|Innate Immunity

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