A potent 5-HT1B inverse agonist (pKi = 8.16) that displays >75-fold selectivity for human 5-HT1B over all other 5-HT receptors

SB-224289 (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
180084-26-8
Storage:
-20
UN-No:
Non-Hazardous - /

The transduction of neurobehavioral effects by serotonin (5-hydroxy tryptamine; 5-HT) is mediated by at least seven major 5-HT receptor subtypes. SB-224289 is a potent 5-HT1B inverse agonist (pKi = 8.16) that displays >75-fold selectivity for human 5-HT1B over all other 5-HT receptors.{27920} It has been used to study the role of 5-HT1B receptors in cocaine self-administration and cocaine-seeking behavior.{27921}  

 

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Description

A potent 5-HT1B inverse agonist (pKi = 8.16) that displays >75-fold selectivity for human 5-HT1B over all other 5-HT receptors

Formal name: [2′-methyl-4′-(5-methyl-1,2,4-oxadiazol-3-yl)[1,1′-biphenyl]-4-yl](2,5,6,7-tetrahydro-1′-methylspiro[3H-furo[2,3-f]indole-3,4′-piperidin]-5-yl)-methanone, monohydrochloride

Synonyms: 

Molecular weight: 557.1

CAS: 180084-26-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Inverse Agonists||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research

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