An inhibitor of Chk1 that blocks phosphorylation of cdc25 with an IC50 value of 15 nM; releases G2 cell cycle arrest induced by γ-irradiation or topotecan

SB 218078 – 1 mg

Brand:
Cayman
CAS:
135897-06-2
Storage:
-20
UN-No:
Non-Hazardous - /

SB 218078 is an inhibitor of checkpoint kinase 1 (Chk1) that blocks phosphorylation of cdc25 with an IC50 value of 15 nM.{31189} It less potently inhibits cdc2 and PKC (IC50s = 250 and 1,000 nM, respectively) and causes 85% inhibition of PKD1 at 1 µM.{31189,29520} SB 218078 releases G2 cell cycle arrest induced by γ-irradiation or the topoisomerase I inhibitor topotecan (Item No. 14129).{31189} In this way, SB 218078 enhances the cytotoxicity of DNA-damaging compounds.{24026}  

 

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Description

An inhibitor of Chk1 that blocks phosphorylation of cdc25 with an IC50 value of 15 nM; releases G2 cell cycle arrest induced by γ-irradiation or topotecan

Formal name: 9,10,11,12-tetrahydro-9,12-epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-dione

Synonyms: 

Molecular weight: 393.4

CAS: 135897-06-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Checkpoint Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Cell Cycle|G2/S||Research Area|Cancer|Cell Signaling||Research Area|Cancer|DNA Damage and Repair||Research Area|Cell Biology|Cell Cycle

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