An inhibitor of GSK3α (IC50 = 34 nM

SB-216763 – 10 mg

Brand:
Cayman
CAS:
280744-09-4
Storage:
-20
UN-No:
Non-Hazardous - /

Glycogen synthase kinase 3 (GSK3) is a serine/threonine protein kinase that is inhibited by an assortment of extracellular stimuli including insulin, growth factors, cell specification factors, and cell adhesion. SB-216763 is a potent and selective cell permeable ATP-competitive inhibitor of GSK3α with an IC50 value of 34 nM (similar potency for GSK3β).{15623} It stimulates glycogen synthesis in Chang human liver cells with an EC50 value of 3.6 µM and induces expression of a β-catenin-LEF/Tcf regulated reporter gene in HEK293 cells.{15623} SB-216763 protects primary neurons from death induced by the PI3-kinase pathway.{15622}  

 

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SKU: 10010246 - 10 mg Category:

Description

An inhibitor of GSK3α (IC50 = 34 nM, GSK3β similar) that stimulates glycogen synthesis in Chang human liver cells (EC50 = 3.6 µM); induces expression of β-catenin-LEF/Tcf regulated reporter genes HEK293 cells

Formal name: 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione

Synonyms: 

Molecular weight: 371.2

CAS: 280744-09-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|GSK3||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling

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