A cell-permeable prodrug of SB 201076; inhibits fatty acid and cholesterol synthesis in HepG2 cells in a concentration-dependent manner; reduces plasma levels of the lipoproteins VLDL

SB 204990 – 1 mg

Brand:
Cayman
CAS:
154566-12-8
Storage:
-20
UN-No:
Non-Hazardous - /

SB 204990 is a cell-permeable prodrug form of SB 201076, an inhibitor of ATP citrate lyase.{37244} SB 204990 inhibits fatty acid and cholesterol synthesis in HepG2 cells in a concentration-dependent manner. Oral administration of SB 204990 (25 mg/kg) reduces plasma levels of the lipoproteins VLDL, LDL, and HDL by 21, 40, and 22%, respectively, in dogs. It also reduces VLDL synthesis and plasma cholesterol and triglyceride levels in rats in a dose-dependent manner.  

 

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Description

A cell-permeable prodrug of SB 201076; inhibits fatty acid and cholesterol synthesis in HepG2 cells in a concentration-dependent manner; reduces plasma levels of the lipoproteins VLDL, LDL, and HDL by 21, 40, and 22%, respectively, in dogs when administered orally at a dose of 25 mg/kg; reduces VLDL synthesis and plasma cholesterol and triglyceride levels in rats in a dose-dependent manner

Formal name: (3R,5S)-rel-5-[6-(2,4-dichlorophenyl)hexyl]tetrahydro-3-hydroxy-2-oxo-3-furanacetic acid

Synonyms: 

Molecular weight: 389.3

CAS: 154566-12-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias

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