A potent

SB 202190 (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
350228-36-3
Storage:
-20
UN-No:
De Minimis - 3077 / 9

SB 202190 is a potent, selective, and cell-permeable inhibitor of p38 MAP kinases, inhibiting p38α (SAPK2A, MAPK14) and p38β (SAPK2B, MAPK11) with IC50 values of 50 and 100 nM, respectively.{21464,12847} When tested at 10 μM, SB 202190 has negligible effects on a range of other kinases, including other MAP kinases such as ERK and JNK.{12847} It directly binds to the ATP binding pocket of p38 MAP kinases.{15221} SB 202190 has been used to elucidate the roles of p38 MAP kinases in inflammatory cytokine expression, nicotine-induced receptor expression, and HIV-mediated depressive disorder.{21463,21466,21467}  

 

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Description

A potent, selective, and cell-permeable inhibitor of p38 MAP kinases; inhibits p38α (SAPK2A, MAPK14) and p38β (SAPK2B, MAPK11) with IC50 values of 50 and 100 nM, respectively; has negligible effects on a range of other kinases when used at a concentration of 10 μM; including other MAP kinases such as ERK and JNK

Formal name: 4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-phenol, monohydrochloride

Synonyms: 

Molecular weight: 367.8

CAS: 350228-36-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|p38 MAPK||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|p38 MAPK Signaling||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Behavioral Neuroscience|Depression

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