A dual antagonist of 5-HT2C (Ki = 125 nM in isolated rat cortex) and 5-HT2B receptors (pA2 = 7.5 in rat stomach fundus preparations); selective for 5-HT2C and 5-HT2B over 5-HT1A

SB-200646 (hydrochloride) – 1 mg

Brand:
Cayman
CAS:
143797-62-0
Storage:
-20
UN-No:
Non-Hazardous - /

SB-200646 is a dual antagonist of the serotonin (5-HT) receptor subtypes 5-HT2C (Ki = 125 nM in isolated rat cortex) and 5-HT2B (pA2 = 7.5 in rat stomach fundus preparations).{54226} It is selective for 5-HT2C and 5-HT2B over 5-HT1A, 5-HT2A, 5-HT1D, 5-HT3, benzodiazepine, GABAA, α1-, α2A-, α2B-, β1-, and β2-adrenergic, dopamine D1 and D2, and histamine H1 receptors (Kis = >10 µM for all). SB-200646 (20 and 40 mg/kg) reverses mCPP-induced hypophagia and decreases in social interaction time, indicating anxiolytic-like behavior, in rats.  

 

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SKU: 30973 - 1 mg Category:

Description

A dual antagonist of 5-HT2C (Ki = 125 nM in isolated rat cortex) and 5-HT2B receptors (pA2 = 7.5 in rat stomach fundus preparations); selective for 5-HT2C and 5-HT2B over 5-HT1A, 5-HT2A, 5-HT1D, 5-HT3, benzodiazepine, GABAA, α1-, α2A-, α2B-, β1-, and β2-adrenergic, dopamine D1 and D2, and histamine H1 receptors (Kis = >10 µM for all); reverses mCPP-induced hypophagia and decreases in social interaction time in rats at 20 and 40 mg/kg

Formal name: N-(1-methyl-1H-indol-5-yl)-N′-3-pyridinyl-urea, monohydrochloride

Synonyms: 

Molecular weight: 302.8

CAS: 143797-62-0

Purity: ≥98%

Formulation: A solid

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