Description
A lignan with diverse biological activities; inhibits LPS-induced expression of the genes encoding iNOS, TNF-α, and COX-2 (IC50s = ≤10 µM for all), as well as LPS-induced activation of NF-κB and nuclear translocation of NF-κB p65 in RAW 264.7 cells; reduces hydrogen peroxide-induced increases in Hsp70 levels and cell death in C2C12 mouse skeletal muscle myoblasts; reduces hepatic formation of TBARS, plasma levels of ALT, and hepatocyte cell death in a mouse model of iron overload-induced liver injury at 10 and 30 mg/kg; reduces infarct size and heart levels of phosphorylated p38 MAPK and JNK in a rat model of myocardial ischemia-reperfusion injury
Formal name: (5aR,7R,8S,8aR,14aS,14bR)-5a,6,7,8,8a,14b-hexahydro-7,8-dimethyl-5H-benzo[kl]bis[1,3]dioxolo[4,5-b:4′,5′-g]xanthen-5-one
Synonyms:
Molecular weight: 356.4
CAS: 177931-17-8
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Natural Products|Lignans||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Cell Biology|Cell Death||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Cell Biology|Cellular Chaperones||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation
