Description
A trichothecene mycotoxin; induces production of ROS, increases in MDA levels, and apoptosis in PC12 cells from 5-100 nM; cytotoxic to HUVECs (IC50 = 6.8 ng/ml), as well as HepG2, A549, A204, U937, and Jurkat cancer cells (IC50s = 1.2-3.4 ng/ml); induces ulceration of the small intestine in, and is lethal to mice (LD50 = 5.69 mg/kg)
Formal name: (2′S,4E,9R,10E,12Z,16R,16aS,18R,19aR,23aR,25R)-6,7,16,16a,19a,22-hexahydro-25-hydroxy-9-[(1S)-1-hydroxyethyl]-16a,21-dimethyl-spiro[5,9:16,18-dimethano-1H,3H,23H-[1,6,12]trioxacyclooctadecino[3,4-d][1]benzopyran-17(18H),2′-oxirane]-3,14(9H)-dione
Synonyms:
Molecular weight: 528.6
CAS: 53126-64-0
Purity: ≥98%
Formulation: A crystalline solid
