A macrocyclic trichothecene mycotoxin; induces cleavage of caspase-3 and PARP in HL-60 cells at 40 nM; cytotoxic to HepG2

Satratoxin G – 1 mg

Brand:
Cayman
CAS:
53126-63-9
Storage:
-20
UN-No:
Non-Hazardous - /

Satratoxin G is a macrocyclic trichothecene mycotoxin that has been found in S. chartarum.{53279,53280} It induces cleavage of caspase-3 and poly(ADP-ribose) polymerase (PARP) in HL-60 cells when used at a concentration of 40 nM and is cytotoxic to HepG2, Hep-2, Caco-2, A204, U937, and Jurkat cells (IC50s = 2.2-9.7 ng/ml).{53281,53282} Intranasal administration of satratoxin G (500 μg/kg) induces apoptosis of olfactory sensory neurons in olfactory epithelium and ethmoid turbinate expression of the genes encoding IL-1α, IL-1β, IL-6, TNF-α, and MIP-2 in mice.{53280} Satratoxin G induces lethality in 4 week-old male mice (LD50 = 1.23 mg/kg, i.p.).{53279}  

 

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SKU: 9003415 - 1 mg Category:

Description

A macrocyclic trichothecene mycotoxin; induces cleavage of caspase-3 and PARP in HL-60 cells at 40 nM; cytotoxic to HepG2, Hep-2, Caco-2, A204, U937, and Jurkat cells (IC50s = 2.2-9.7 ng/ml); intranasal administration induces apoptosis of olfactory sensory neurons in olfactory epithelium and ethmoid turbinate expression of the genes encoding IL-1α, IL-1β, IL-6, TNF-α, and MIP-2 in mice at 500 μg/kg; induces lethality in 4 week-old male mice (LD50 = 1.23 mg/kg, i.p.)

Formal name: 6,8a,11a,12,21,22-hexahydro-23-hydroxy-19-(1-hydroxyethyl)-7,11a-dimethyl-spiro[10,12:19,22a-dimethano-4H,5H,22aH-oxireno[8,9][1,6,12]trioxacyclooctadecino[3,4-d][1]benzopyran-11(10H),2′-oxirane]-2,14(1aH,19H)-dione

Synonyms: 

Molecular weight: 544.6

CAS: 53126-63-9

Purity: ≥98%

Formulation: A crystalline solid

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