A steroid sapogenin; inhibits proliferation of HeLa cervical

Sarsasapogenin – 250 mg

Brand:
Cayman
CAS:
126-19-2
Storage:
-20
UN-No:
Non-Hazardous - /

Sarsasapogenin is a steroid sapogenin originally isolated from Smilax that has antiproliferative, pro-apoptotic, anti-inflammatory, neuroprotective, and antidepressant-like properties.{41855,41856,41857,36061,41858,41859} Sarsasapogenin inhibits proliferation of HeLa cervical, MCF-7 breast, HepG2 liver, A549 lung, A375.S2 melanoma, and HT-1080 fibrosarcoma cells (IC50s = 31.36-48.79 μM) and dose-dependently induces apoptosis of HeLa cells.{41856,41857} It also protects human SH-SY5Y neuroblastoma cells from hydrogen peroxide-induced death with a neuroprotective ratio of 27.3% when used at a concentration of 100 μM.{41858} In vivo, sarsasapogenin (10 mg/kg) reduces 2,3,4-trinitrobenzene sulfonic acid-induced colon shortening, myeloperoxidase activity, NF-κB activation, and IL-1β, TNF-α, and IL-6 levels in mice.{36061} It also increases the percentage of correct responses in the Y-maze test in aged rats when administered at a dose of 3.6 mg/kg per day.{41860} Sarsasapogenin (12.5 mg/kg per day) reduces the amount of time mice spend immobile in the forced swim test, indicating antidepressant-like behavior.{41859}  

 

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Description

A steroid sapogenin; inhibits proliferation of HeLa cervical, MCF-7 breast, HepG2 liver, A549 lung, A375.S2 melanoma, and HT-1080 fibrosarcoma cells (IC50s = 31.36-48.79 μM); dose-dependently induces apoptosis of HeLa cells; protects human SH-SY5Y neuroblastoma cells from hydrogen peroxide-induced death with a neuroprotective ratio of 27.3% at 100 μM; reduces 2,3,4-trinitrobenzene sulfonic acid-induced colon shortening, myeloperoxidase activity, NF-κB activation, and IL-1β, TNF-α, and IL-6 levels in mice at 10 mg/kg; increases the percentage of correct responses in the Y-maze test in aged rats at 3.6 mg/kg per day; reduces the amount of time mice spend immobile in the forced swim test at 12.5 mg/kg per day

Formal name: (3β,5β,25S)-spirostan-3-ol

Synonyms:  NSC 1615

Molecular weight: 416.6

CAS: 126-19-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Saponins||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Neuroprotection

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