An intermediate in the biosynthesis of glycine; a selective inhibitor of GlyT1 (IC50s = 91 and >1

Sarcosine – 250 g

Brand:
Cayman
CAS:
107-97-1
Storage:
-20
UN-No:
Non-Hazardous - /

Sarcosine is an intermediate in the biosynthesis of glycine from choline.{48332} It is a selective inhibitor of glycine transporter 1 (GlyT1) with IC50 values of 91 and greater than 1,000 µM for GlyT1 and GlyT2, respectively, in HEK293 cells expressing the human transporters.{48333} Sarcosine levels are increased in prostate cancer cell lines with an invasive phenotype compared with non-invasive cell lines.{48334} Sarcosine increases in a progressive fashion in prostate cancer with 0, 42, and 79% of benign, localized, and metastatic prostate tissue samples containing increased levels of sarcosine.  

 

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SKU: 26799 - 250 g Category:

Description

An intermediate in the biosynthesis of glycine; a selective inhibitor of GlyT1 (IC50s = 91 and >1,000 µM for GlyT1 and GlyT2, respectively); increased in prostate cancer cell lines with an invasive phenotype compared with non-invasive cell lines; increases in a progressive fashion in prostate cancer with 0, 42, and 79% of benign, localized, and metastatic prostate tissue samples containing increased levels of sarcosine

Formal name: N-methyl-glycine

Synonyms: 

Molecular weight: 89.1

CAS: 107-97-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cancer|Cell Migration & Metastasis

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