A TRPC6 channel blocker (IC50 = 7.9 nM); selective for TRPC6 over TRPC4 and TRPC5 (IC50s = 282 and 226 nM

SAR7334 (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
1333207-63-8
Storage:
-20
UN-No:
Non-Hazardous - /

SAR7334 is a transient receptor potential canonical 6 (TRPC6) channel blocker (IC50 = 7.9 nM).{47571} It is selective for TRPC6 over TRPC4 and TRPC5 (IC50s = 282 and 226 nM, respectively). SAR7334 (0.2-1 μM) blocks TRPC6-dependent hypoxia-induced vasoconstriction in isolated perfused and ventilated mouse lung. It also inhibits oxidative stress-induced apoptosis and increases autophagic flux in primary mouse renal proximal tubule cells.{47572}  

 

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SKU: 28292 - 5 mg Category:

Description

A TRPC6 channel blocker (IC50 = 7.9 nM); selective for TRPC6 over TRPC4 and TRPC5 (IC50s = 282 and 226 nM, respectively); blocks TRPC6-dependent hypoxia-induced vasoconstriction in isolated perfused and ventilated mouse lung from 0.2-1 μM; inhibits oxidative stress-induced apoptosis and increases autophagic flux in primary mouse renal proximal tubule cells

Formal name: 4-[[(1R,2R)-2-[(3R)-3-amino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro-benzonitrile, dihydrochloride

Synonyms: 

Molecular weight: 440.8

CAS: 1333207-63-8

Purity: ≥98%

Formulation: A crystalline solid

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