A selective inhibitor of Vps34 (IC50 = 1.2 nM); alters vesicle trafficking and inhibits autophagy by blocking autophagosome formation; synergizes with everolimus in preventing the proliferation of renal tumor cell lines

SAR405 – 5 mg

Brand:
Cayman
CAS:
1523406-39-4
Storage:
-20
UN-No:
De Minimis - 3077 / 9

SAR405 is an inhibitor of the phosphoinositide 3-kinase (PI3K) class III isoform Vps34 (IC50 = 1.2 nM).{27429} It is without effect (IC50 > 10,000 nM) on other PI3K isoforms and mTOR. SAR405 alters vesicle trafficking and inhibits autophagy by blocking autophagosome formation.{27429} SAR405 also synergizes with the mTOR inhibitor everolimus (Item No. 11597) in preventing the proliferation of renal tumor cell lines.{27429}  

 

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Description

A selective inhibitor of Vps34 (IC50 = 1.2 nM); alters vesicle trafficking and inhibits autophagy by blocking autophagosome formation; synergizes with everolimus in preventing the proliferation of renal tumor cell lines

Formal name: (8S)-9-[(5-chloro-3-pyridinyl)methyl]-6,7,8,9-tetrahydro-2-[(3R)-3-methyl-4-morpholinyl]-8-(trifluoromethyl)-4H-pyrimido[1,2-a]pyrimidin-4-one

Synonyms: 

Molecular weight: 443.9

CAS: 1523406-39-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PI3K||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Autophagy||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cell Biology|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy

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