A selective inhibitor of PI3Kβ (IC50 = 52 nM); demonstrates significant in vivo activity in a UACC-62 xenograft model in mice

SAR260301 – 1 mg

Brand:
Cayman
CAS:
1260612-13-2
Storage:
-20
UN-No:
Non-Hazardous - /

SAR260301 is an inhibitor of phosphatidylinositol 3-kinase (PI3K) isoform β (IC50 = 52 nM).{34311} It is selective for p110β over other PI3K isoforms.{34311} SAR260301 demonstrates significant in vivo activity in a UACC-62 xenograft model in mice.{34311} It has synergistic antitumor activity when combined with the BRAF inhibitor vemurafenib (PLX4032; Item No. 10618) or the MEK inhibitor selumetinib (AZD 6244; Item No. 11599) in PTEN-deficient/BRAF-mutated human melanoma tumor models.{34310}  

 

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Description

A selective inhibitor of PI3Kβ (IC50 = 52 nM); demonstrates significant in vivo activity in a UACC-62 xenograft model in mice

Formal name: 2-[2-[(2S)-2,3-dihydro-2-methyl-1H-indol-1-yl]-2-oxoethyl]-6-(4-morpholinyl)-4(3H)-pyrimidinone

Synonyms: 

Molecular weight: 354.4

CAS: 1260612-13-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PI3K||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling

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