A JAK family kinase inhibitor (IC50s = 0.6

SAR20347 – 1 mg

Brand:
Cayman
CAS:
1450881-55-6
Storage:
-20
UN-No:
Non-Hazardous - /

SAR20347 is an inhibitor of the JAK family kinases TYK2 and JAK1-3 (IC50s = 0.6, 23, 26, and 41 nM, respectively, in cell-free assays).{52137} It inhibits IL-12-induced TYK2-dependent phosphorylation of STAT4 in NK-92 cells (IC50 = 126 nM) and IL-6-induced JAK1-dependent STAT3 signaling in TF-1 cells (IC50 = 345 nM). SAR20347 (5 μM) inhibits IL-12-induced INF-γ production and reporter gene activity in peripheral blood mononuclear cells (PBMCs). In vivo, SAR20347 (60 mg/kg) inhibits the production of serum IFN-γ in mice. SAR20347 also reduces keratinocyte activation and skin levels of IL-12, IL-23, IL-6, IL-22, and IFN-γ in a mouse model of psoriasis induced by imiquimod (Item No. 14956).  

 

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SKU: 29248 - 1 mg Category:

Description

A JAK family kinase inhibitor (IC50s = 0.6, 23, 26, and 41 nM, for TYK2 and JAK1-3, respectively, in cell-free assays); inhibits IL-12-induced TYK2-dependent phosphorylation of STAT4 in NK-92 cells (IC50 = 126 nM) and IL-6-induced JAK1-dependent phosphorylated STAT3 signaling in TF-1 cells (IC50 = 345 nM); inhibits IL-12-induced INF-γ production and reporter gene activity in PBMCs at 5 μM; inhibits the production of serum IFN-γ in mice at 60 mg/kg; reduces keratinocyte activation and skin levels of IL-12, IL-23, IL-6, IL-22 and IFN-γ in a mouse model of imiquimod-induced psoriasis

Formal name: 2-(2-chloro-6-fluorophenyl)-5-[[4-(4-morpholinylcarbonyl)phenyl]amino]-4-oxazolecarboxamide

Synonyms: 

Molecular weight: 444.8

CAS: 1450881-55-6

Purity: ≥98%

Formulation: A solid

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