A Smo receptor antagonist; binds to the Smo receptor (Kd = 12 nM) and inhibits binding of SAG and cyclopamine (Kis = 7.8 and 8.4 nM

SANT-2 – 50 mg

Brand:
Cayman
CAS:
329196-48-7
Storage:
-20
UN-No:
Non-Hazardous - /

SANT-2 is a Smoothened (Smo) receptor antagonist.{21771,24191} It binds to the Smo receptor (Kd = 12 nM) and inhibits binding of the Smo receptor agonist SAG-1.3 (SAG; Item No. 11914) and antagonist cyclopamine (Item No. 11321) (Kis = 7.8 and 8.4 nM, respectively). SANT-2 inhibits hedgehog signaling induced by an N-terminal fragment of sonic hedgehog (Shh) in an Shh-LIGHT2 cellular assay (IC50 = 30 nM).{21771}  

 

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SKU: 21208 - Category:

Description

A Smo receptor antagonist; binds to the Smo receptor (Kd = 12 nM) and inhibits binding of SAG and cyclopamine (Kis = 7.8 and 8.4 nM, respectively); inhibits hedgehog signaling induced by an N-terminal fragment of Shh in an Shh-LIGHT2 cellular assay (IC50 = 30 nM)

Formal name: N-[3-(1H-benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxy-benzamide

Synonyms: 

Molecular weight: 480

CAS: 329196-48-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cell Biology|Cell Signaling|Hedgehog Signaling

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