A benzylisoquinoline alkaloid that exhibits antimicrobial

Sanguinarine (chloride) – 10 mg

Brand:
Cayman
CAS:
5578-73-4
Storage:
-20
UN-No:
Non-Hazardous - /

Sanguinarine is a benzylisoquinoline alkaloid isolated from plants belonging to the family Papaveraceae.{22467} It exhibits antimicrobial, anti-inflammatory, and anti-oxidant properties and demonstrates antiproliferative and pro-apoptotic effects in some cancer cell lines. Sanguinarine suppresses NF-κB activation by blocking the degradation of IκBα and sensitizes cancer cells to apoptosis by inducing ROS generation and activating TNF-related apoptosis-inducing ligand.{25057} Furthermore, sanguinarine has been shown to reduce cancer cell metastasis though the inhibition of MMP-2 and MMP-9 activation and to exhibit antiangiogenic activity by downregulating VEGF-induced Akt activation.{25057}  

 

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Description

A benzylisoquinoline alkaloid that exhibits antimicrobial, anti-inflammatory, and anti-oxidant properties and demonstrates antiproliferative and pro-apoptotic effects in some cancer cell lines

Formal name: 13-methyl-[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium, monochloride

Synonyms: 

Molecular weight: 367.8

CAS: 5578-73-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cancer|Transcription Factors|NF-κB||Research Area|Cancer|Tumor Microenvironment||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity

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