A flavonoid with diverse biological activities; inhibits TNF-α- or IL-1β-induced PMN adhesion to HSCs (IC50s = 27.29 and 54.43 nM

Sanggenone C – 5 mg

Brand:
Cayman
CAS:
80651-76-9
Storage:
-20
UN-No:
Non-Hazardous - /

Sanggenone C is a flavonoid that has been found in mulberry bark and has diverse biological activities.{48989,48990,48991,48992} It inhibits TNF-α- or IL-1β-induced polymorphonuclear leukocyte (PMN) adhesion to human synovial cells (HSCs; IC50s = 27.29 and 54.43 nM, respectively), as well as inhibits NF-κB activation in HSCs.{48989} Sanggenone C induces apoptosis and production of reactive oxygen species (ROS) in HT-29 cells when used at concentrations ranging from 10 to 40 µM.{48990} It decreases cell viability of HT-29 cells in vitro and reduces tumor growth in an HT-29 mouse xenograft model when administered at a dose of 10 mg/kg. Sanggenone C increases vertebrate column bone mineralization in a zebrafish model of prednisone-induced osteoporosis.{48991} It also attenuates cardiac hypertrophy and fibrosis and reduces activation of nuclear factor of activated T cells 2 (NFAT2) in a mouse model of pressure overload-induced cardiac hypertrophy.{48992}  

 

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SKU: 30061 - 5 mg Category:

Description

A flavonoid with diverse biological activities; inhibits TNF-α- or IL-1β-induced PMN adhesion to HSCs (IC50s = 27.29 and 54.43 nM, respectively); inhibits NF-κB activation in HSCs; induces apoptosis and production of ROS in HT-29 cells from 10-40 µM; decreases cell viability of HT-29 cells in vitro and reduces tumor growth in an HT-29 mouse xenograft model at 10 mg/kg; increases vertebrate column bone mineralization in a zebrafish model of prednisone-induced osteoporosis; attenuates cardiac hypertrophy and fibrosis and reduces activation of NFAT2 in a mouse model of pressure overload-induced cardiac hypertrophy

Formal name: (5aR,10aS)-2-[(1S,5S,6R)-6-(2,4-dihydroxybenzoyl)-5-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexen-1-yl]-5a,10a-dihydro-1,3,8,10a-tetrahydroxy-5a-(3-methyl-2-buten-1-yl)-11H-benzofuro[3,2-b][1]benzopyran-11-one

Synonyms: 

Molecular weight: 708.7

CAS: 80651-76-9

Purity: ≥98%

Formulation: A crystalline solid

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