A potent KOR agonist; almost as potent as salvinorin A (EC50 = 6.2 and 4.5 nM for salvinorin A carbamate and salvinorin A

Salvinorin A Carbamate – 1 mg

Brand:
Cayman
CAS:
858345-57-0
Storage:
-20
UN-No:
Non-Hazardous - /

Salvinorin A carbamate is a potent κ-opioid receptor (KOR) full agonist that is almost as potent as salvinorin A (Item No. 11487) with EC50 values of 6.2 and 4.5 nM, respectively, for activation of the human KOR to enhance binding of [35S]GTPγS.{36003} The addition of a carbamate group to salvinorin A increases biological stability by decreasing deacetylation.  

 

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Description

A potent KOR agonist; almost as potent as salvinorin A (EC50 = 6.2 and 4.5 nM for salvinorin A carbamate and salvinorin A, respectively); has increased biological stability compared to salvinorin A ,

Formal name: (2S,4aR,6aR,7R,9S,10aS,10bR)-9-[(aminocarbonyl)oxy]-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid, methyl ester

Synonyms: 

Molecular weight: 433.5

CAS: 858345-57-0

Purity: ≥90%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Pain Research

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