A prodrug of sodium salicylate that can reduce blood glucose

Salsalate – 100 g

Brand:
Cayman
CAS:
552-94-3
Storage:
-20
UN-No:
Limited Quantity - 3077 / 9

Nonacetylated (e.g., sodium salicylate) and acetylated (aspirin) forms of salicylate are widely used to target inflammation in the treatment of insulin resistance, type 2 diabetes, or rheumatic pain.{21029} Salsalate is a dimeric prodrug comprising two esterified salicylate moieties. It is advantageous over sodium salicylate because it is insoluble at the acid pH of the stomach and passes suspended but undissolved into the small intestine, sparing the gastric mucosa direct contact.{21206} Proof-of-principle clinical studies demonstrate that 3-4.5 g/d salsalate can reduce blood glucose, triglyceride, free fatty acid and C-reactive protein concentrations, improve glucose utilization, and increase circulating insulin and adiponectin concentrations in obese adults at risk for the development of type 2 diabetes as well as for patients with type 2 diabetes.{21204,21205,21206}  

 

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SKU: 11911 - 100 g Category:

Description

A prodrug of sodium salicylate that can reduce blood glucose, triglyceride, free fatty acid and C-reactive protein concentrations; can improve glucose utilization; and can increase circulating insulin and adiponectin concentrations in obese adults at risk for the development of type 2 diabetes and in patients with type 2 diabetes

Formal name: 2-hydroxy-2-carboxyphenyl ester-benzoic acid

Synonyms:  Disalcid|Nobacid|NSC 49171|Salflex|Salina|Sasapirin

Molecular weight: 258.2

CAS: 552-94-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis

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