A glycoside; scavenges DPPH and ABTS radicals (EC50s = 81.54 and 30.94 µg/ml

Salidroside – 5 mg

Brand:
Cayman
CAS:
10338-51-9
Storage:
-20
UN-No:
Non-Hazardous - /

Salidroside is a glycoside that has been found in R. rosea and has diverse biological activities, including antioxidant, anti-apoptotic, neuroprotective, and anti-inflammatory properties.{17556,48899,48900,48901,18152} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and ABTS (Item No. 27317) radicals with EC50 values of 81.54 and 30.94 µg/ml, respectively, in cell-free assays.{48899} Salidroside (50 and 100 µM) inhibits apoptosis and production of reactive oxygen species (ROS) induced by amyloid-β (25-35) (Aβ (23-35)) in SH-SY5Y neuroblastoma cells.{48900} It decreases infarct volume by 17.9% in a rat model of focal cerebral ischemia-reperfusion injury induced by transient middle cerebral artery occlusion (MCAO) when administered at a dose of 12 mg/kg.{48901} Salidroside (20, 50, and 100 mg/kg, p.o.) increases survival and reduces plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST), TNF-α, and malondialdehyde (MDA) levels in a mouse model of liver injury induced by acetaminophen (Item No. 10024).{18152}  

 

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Description

A glycoside; scavenges DPPH and ABTS radicals (EC50s = 81.54 and 30.94 µg/ml, respectively, in cell-free assays); inhibits apoptosis and production of ROS induced by Aβ (23-35) in SH-SY5Y neuroblastoma cells at 50 and 100 µM; decreases infarct volume by 17.9% in a rat model of focal cerebral ischemia-reperfusion injury induced by MCAO at 12 mg/kg; increases survival and reduces plasma ALT, AST, TNF-α, and MDA levels in a mouse model of acetaminophen-induced liver injury

Formal name: 2-(4-hydroxyphenyl)ethyl-β-D-glucopyranoside

Synonyms:  Rhodioloside

Molecular weight: 300.3

CAS: 10338-51-9

Purity: ≥97%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Glycosides||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease||Research Area|Neuroscience|Neuroprotection|Ischemia||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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