An internal standard for the quantification of salbutamol by GC- or LC-MS

Salbutamol-d9 – 500 µg

Brand:
Cayman
CAS:
1173021-73-2
Storage:
-20
UN-No:
Non-Hazardous - /

Salbutamol-d9 is intended for use as an internal standard for the quantification of salbutamol (Item Nos. 21003 | 23991) by GC- or LC-MS. Salbutamol is an agonist of the β2-adrenergic receptor (β2-AR; Kd = 759 nM in a radioligand binding assay using CHO cells expressing the human receptor).{25151} It is selective for β2-ARs over β1- and β3-ARs (Kds = 46.8 and 21.9 µM, respectively). Salbutamol (25-50 μg/kg, i.v.) reduces acetylcholine-induced bronchospasm in anesthetized guinea pigs.{40769} It also reduces response of bronchial muscle to efferent vagal stimulation in anesthetized cats and dogs when administered at doses ranging from 1 to 2.5 and 10 to 20 µg/kg, respectively. Nebulized salbutamol reduces transpulmonary pressure in recurrent airway obstruction-affected horses (EC50 = 39.7 µg).{40770} Formulations containing salbutamol have been used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).  

 

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SKU: 25234 - 500 µg Category:

Description

An internal standard for the quantification of salbutamol by GC- or LC-MS

Formal name: α1-[[[1,1-di(methyl-d3)ethyl-2,2,2-d3]amino]methyl]-4-hydroxy-1,3-benzenedimethanol

Synonyms:  (±)-Salbutamol-d9|DL-Salbutamol-d9

Molecular weight: 248.4

CAS: 1173021-73-2

Purity: ≥99% deuterated forms (d1-d9)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Cardiovascular Diseases||Research Area|Cardiovascular System|Heart|Arrhythmia||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma||Research Area|Immunology & Inflammation|Pulmonary Diseases|COPD/Emphysema

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