A depsidone lichen metabolite; active against B. cereus

Salazinic Acid – 1 mg

Brand:
Cayman
CAS:
521-39-1
Storage:
-20
UN-No:
Non-Hazardous - /

Salazinic acid is a depsidone lichen metabolite that has been found in P. sulcata.{48819} It is active against B. cereus, B. subtilis, S. aureus, P. aeruginosa, S. typhimurium, C. albicans, and A. niger in vitro (MICs = 3.9-30.8 mM). Salazinic acid is cytotoxic to MM98, A431, and HaCaT cells in crystal violet (EC50s = 159, 2,870, and 48 μM, respectively) and neutral red uptake assays (EC50s = 1,925, 1,913, and 907 μM, respectively).{50294} It increases the wound closure rate in scratch-wounded HaCaT monolayers and increases HaCaT cell migration in a transwell assay when used at a concentration of 30 μM.  

 

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Description

A depsidone lichen metabolite; active against B. cereus, B. subtilis, S. aureus, P. aeruginosa, S. typhimurium, C. albicans, and A. niger in vitro (MICs = 3.9-30.8 mM); cytotoxic to MM98, A431, and HaCaT cells in crystal violet (EC50s = 159, 2,870, and 48 μM, respectively) and neutral red uptake assays (EC50s = 1,925, 1,913, and 907 μM, respectively); increases the wound closure rate in scratch-wounded HaCaT monolayers and increases HaCaT cell migration in a transwell assay at 30 μM

Formal name: 1,3-dihydro-1,4,10-trihydroxy-5-(hydroxymethyl)-8-methyl-3,7-dioxo-7H-isobenzofuro[4,5-b][1,4]benzodioxepin-11-carboxaldehyde

Synonyms:  NSC 87509

Molecular weight: 388.3

CAS: 521-39-1

Purity: ≥95%

Formulation: A solid

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