An inhibitor of eIF2α dephosphorylation; more potent derivative of salubrinal; increases eIF2α phosphorylation in MEFs when used at a concentration of 10 µM; impairs late-phase LTP in mouse hippocampal slices; impairs context fear memory in rats

Sal-003 – 10 mg

Brand:
Cayman
CAS:
1164470-53-4
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Sal-003 dose-dependently prevents dephosphorylation of eukaryotic translation initiation factor 2 subunit α (eIF2α).{38357} It is a more potent derivative of salubrinal (Item No. 14735) that increases eIF2α phosphorylation in mouse embryonic fibroblasts (MEFs) when used at a concentration of 10 µM.{38356} It impairs late-phase long-term potentiation (LTP) in hippocampal slices from wild-type, but not ATF4 knockout, mice. When infused into the dorsal hippocampus post-training, Sal-003 impairs contextual fear memory in rats.  

 

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SKU: 23414 - 10 mg Category:

Description

An inhibitor of eIF2α dephosphorylation; more potent derivative of salubrinal; increases eIF2α phosphorylation in MEFs when used at a concentration of 10 µM; impairs late-phase LTP in mouse hippocampal slices; impairs context fear memory in rats

Formal name: (2E)-3-phenyl-N-[2,2,2-trichloro-1-[[[(4-chlorophenyl)amino]thioxomethyl]amino]ethyl]-2-propenamide

Synonyms: 

Molecular weight: 463.2

CAS: 1164470-53-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory

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