A SMO agonist (EC50 = 3 nM) which inhibits hedgehog signaling at high concentrations (>1 μM); directly binds to SMO and can block SMO inhibition by cyclopamine; at 15-240 nM

SAG – 5 mg

Brand:
Cayman
CAS:
912545-86-9
Storage:
-20
UN-No:
Non-Hazardous - /

Smoothened agonist (SAG) is a chlorobenzothiophene-containing compound which acts as a SMO agonist (EC50 = 3 nM) but inhibits hedgehog signaling at high concentrations (>1 μM).{21771} It directly binds to SMO and can block SMO inhibition by cyclopamine.{21771} Binding of SAG alters the conformation of SMO, leading to its accumulation in cilia and activation of gene transcription.{20488,21775,21773} At 15-240 nM, SAG prevents the neurotoxic effects of glucocorticoids without interfering with the beneficial effects of glucocorticoids on lung maturation.{21772} At higher concentrations (0.4 mM), SAG improves the conversion of human induced pluripotent stem cells to the neural lineage.{21770}  

 

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SKU: 11914 - 5 mg Category:

Description

A SMO agonist (EC50 = 3 nM) which inhibits hedgehog signaling at high concentrations (>1 μM); directly binds to SMO and can block SMO inhibition by cyclopamine; at 15-240 nM, prevents the neurotoxic effects of glucocorticoids; at 0.4 mM, improves the conversion of iPSC to the neural lineage

Formal name: 3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-benzo[b]thiophene-2-carboxamide

Synonyms:  Smoothened Agonist

Molecular weight: 490.1

CAS: 912545-86-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cell Biology|Cell Signaling|Hedgehog Signaling||Research Area|Cell Biology|Stem Cell Research|Differentiation||Research Area|Neuroscience|Neuroprotection

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