A selective suppressor of electron leak from mitochondrial respiratory complex III (IC50 value of 1.7 µM for inhibition of superoxide production); protects against ROS-induced cell stress and HIF-1α induction in response to hypoxia

S3QEL-2 – 25 mg

Brand:
Cayman
CAS:
890888-12-7
Storage:
-20
UN-No:
Non-Hazardous - /

S3QEL-2 is a cell-permeable, selective suppressor of electron leak from mitochondrial respiratory complex III, inhibiting site IIIQo superoxide production (IC50 = 1.7 µM) without altering normal bioenergetics function.{29803} It reduces production of H2O2 during oxidation of glutamate plus malate to 25% of the control level. S3QEL-2 also protects against ROS-induced cell stress in pancreatic β-cells and decreases HIF-1α induction in response to hypoxia.  

 

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Description

A selective suppressor of electron leak from mitochondrial respiratory complex III (IC50 value of 1.7 µM for inhibition of superoxide production); protects against ROS-induced cell stress and HIF-1α induction in response to hypoxia

Formal name: 1-(3,4-dimethylphenyl)-N,N-dipropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Synonyms: 

Molecular weight: 323.4

CAS: 890888-12-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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