An inhibitor of STAT3 transcription factor activation

S3I-201 – 10 mg

Brand:
Cayman
CAS:
501919-59-1
Storage:
-20
UN-No:
Non-Hazardous - /

Signal transducers and activators of transcription (STATs) are a family of latent cytoplasmic transcription factors that convey signals from the cell membrane to the nucleus. In various human tumors, STAT3 is constitutively activated by aberrant upstream tyrosine kinase activities.{23053} STAT signaling is also suspected to play a role in vascular disease since it can be activated through angiotensin II type 1 receptors or the inflammatory mediator interleukin (IL)-6.{23262} S3I-201 is an inhibitor of STAT3 transcription factor activation, dimerization, and gene transcription. It can suppress IL-6-induced phosphorylation of STAT3 in T cells with an IC50 value of 38 μM.{23263} Inhibiting STAT3 activation with 10 μM S3I-201 was demonstrated to be protective against angiotensin II-induced oxidative stress, endothelial dysfunction, and hypertension in two different models of vascular disease.{23262} At 10 μM, S3I-201 has also been used as a means to regress cardiac hypertrophy by inhibiting collagen biosynthesis and decreasing atrial natriuretic factor and β-myosin heavy chain in an in vitro model.{23264}  

 

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Description

An inhibitor of STAT3 transcription factor activation, dimerization, and gene transcription; suppresses IL-6-induced phosphorylation of STAT3 in T cells (IC50 = 38 μM) and is protective against angiotensin II-induced vascular dysfunction

Formal name: 2-hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoic acid

Synonyms:  NSC 74859

Molecular weight: 365.4

CAS: 501919-59-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Heart|Myocardial Hypertrophy||Research Area|Cardiovascular System|Vasculature|Endothelium||Research Area|Immunology & Inflammation|Adaptive Immunity

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