A potent and selective inhibitor of autotaxin

S32826 – 10 mg

Brand:
Cayman
CAS:
1096770-84-1
Storage:
-20
UN-No:
Non-Hazardous - /

Autotaxin is a lysophospholipase D, cleaving lysophosphatidylcholine to produce choline and lysophosphatidic acid (LPA). S32826 is a potent and selective inhibitor of autotaxin, inhibiting recombinant autotaxin β with an IC50 of 8.8 nM.{17756} It shows similar effectiveness against the three known autotaxin isoforms (α, β, and γ). It has no effect on a variety of receptors and enzymes, with the exceptions of src (IC50 = 6 μM) and phosphatase 1B (IC50 = 15 μM).{17756} S32826 inhibits LPA release from adipocytes (IC50 = 90 nM) and reduces plasma autotaxin activity by 57% when used at 5 μM.{17756}  

 

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Description

A potent and selective inhibitor of autotaxin, inhibiting recombinant autotaxin β with an IC50 value of 8.8 nM; inhibits LPA release from adipocytes (IC50 = 90 nM) and reduces plasma autotaxin activity by 57% when used at 5 μM

Formal name: P-[[4-[(1-oxotetradecyl)amino]phenyl]methyl]-phosphonic acid

Synonyms: 

Molecular weight: 397.5

CAS: 1096770-84-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phospholipases||Research Area|Cell Biology|Cell Signaling

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