Description
A PPARγ agonist (EC50 = 8.83 nM in a transactivation assay); selective for PPARγ over PPARα, PPARβ/δ, and RXRα at 10 μM; decreases serum levels of glucose, triglycerides, non-esterified fatty acids, and insulin and increases hepatic palmitate oxidation in an ob/ob mouse model of type 2 diabetes at 30 mg/kg per day; decreases plasma levels of triglycerides and total and non-HDL cholesterol and the surface area of atherosclerotic lesions in the aortic sinus in an E2-KI transgenic mouse model of dyslipidemia and atherosclerosis fed a Western diet at 30 mg/kg
Formal name: 2-[[4-[2-(6-benzoyl-2-oxo-3(2H)-benzothiazolyl)ethoxy]phenyl]methyl]-propanedioic acid, 1,3-dimethyl ester
Synonyms:
Molecular weight: 519.6
CAS: 353280-43-0
Purity: ≥98%
Formulation: A solid
