Description
Sphingosine-1-phosphate (S1P) exerts its activity by binding to five distinct G-protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8.{11895,12477} S1P3 couples to Gi/o-ERK, Gq-PLC, and G12/13-Rho axes to mediate S1P-induced cell proliferation, survival, migration, and related signaling events.{11895,12477,10628} S1P3 is widely expressed in various tissues, suggesting diverse physiological functions of this receptor.{10623} The human and mouse S1P3 have 378 amino acids with an estimated molecular weight of 42 kDa. Glycosylation at the N-terminal extracellular domain may cause the protein to migrate at different positions in SDS-PAGE. Cayman’s S1P3 Polyclonal Antibody can be used for immunocytochemistry and Western blot applications. The antibody recognizes S1P3 at 47 kDa from human, mouse, and rat samples. Liver and heart tissues display 2-3 bands between 40-50 kDa, possibly due to different degree of glycosylation.
Synonyms: EDG-3|S1PR3|Sphingosine-1-phosphate Receptor 3
Immunogen: Synthetic peptide from the N-terminal region of human S1P3
Formulation: Peptide affinity-purified antibody lyophilized from 500 µl
Isotype:
Applications: ICC and WB
Origin: Animal/Rabbit
Stability: 365 days
Application|Immunocytochemistry||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Lipid Biochemistry|Sphingolipids
