A positive allosteric modulator of AMPA receptors that potently enhances (S)-AMPA-mediated noradrenaline release in rat hippocampal and frontal cortex slices; orally bioavailable and BBB penetrant

S18986 – 5 mg

Brand:
Cayman
CAS:
175340-20-2
Storage:
-20
UN-No:
Non-Hazardous - /

S18986 is a positive allosteric modulator of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors that potently enhances (S)-AMPA-mediated noradrenaline release in rat hippocampal and frontal cortex slices.{33738} S18986 is orally bioavailable and penetrates the blood-brain barrier in animals.{33737} Formulations containing S18986 improve episodic memory in rats.{33737} S18986 is used to elucidate the roles of AMPA receptor signaling in cells and in animals.{33737,33739,33740}  

 

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Description

A positive allosteric modulator of AMPA receptors that potently enhances (S)-AMPA-mediated noradrenaline release in rat hippocampal and frontal cortex slices; orally bioavailable and BBB penetrant,

Formal name: 2,3,3aS,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine, 5,5-dioxide

Synonyms: 

Molecular weight: 224.3

CAS: 175340-20-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Allosteric Modulators||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory

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