A small molecule inhibitor of cyclins D1-D3 expression that inhibits PI3K activity and arrests cells at the G0/G1 phase in a dose-dependent manner (5-10 μM); induces apoptosis in myeloma and leukemia cell lines (IC50s = < 10 μM) and delays tumor growth in mouse models of leukemia

S14161 – 5 mg

Brand:
Cayman
CAS:
883046-50-2
Storage:
-20
UN-No:
Non-Hazardous - /

D-Cyclins regulate the cell cycle by acting in a complex with cyclin dependent kinases (CDKs) to promote phosphorylation of the retinoblastoma protein and initiate cellular progression from the G1 to the S phase. Cell cycle deregulation in many cancers often results from altered cyclin D/CDK activity. S14161 is a small molecule inhibitor of cyclins D1-D3 expression that inhibits phosphoinositide 3-kinase activity and arrests cells at the G0/G1 phase in a dose-dependent manner (concentrations tested from 5-10 μM).{22193} S14161 induces apoptosis in myeloma and leukemia cell lines (IC50s 20 > 25 μM).{22193} In a mouse model of leukemia, S14161 delayed tumor growth by up to 90% compared to controls at a dose of 100 mg/kg/day.{22193}  

 

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Description

A small molecule inhibitor of cyclins D1-D3 expression that inhibits PI3K activity and arrests cells at the G0/G1 phase in a dose-dependent manner (5-10 μM); induces apoptosis in myeloma and leukemia cell lines (IC50s = < 10 μM) and delays tumor growth in mouse models of leukemia

Formal name: 8-ethoxy-2-(4-fluorophenyl)-3-nitro-2H-1-benzopyran

Synonyms: 

Molecular weight: 315.3

CAS: 883046-50-2

Purity: ≥99%

Formulation: A solid

Product Type|Biochemicals|Kinase Inhibitors|PI3K||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle|G1||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling

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