The inactive enantiomer of the SET7/9 inhibitor (R)-PFI-2 that may serve as a negative control

(S)-PFI-2 (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
1627607-88-8
Storage:
-20
UN-No:
Non-Hazardous - /

SET domain-containing protein 7/9 (SET7/9) is a histone methyltransferase that monomethylates lysine 4 of histone H3, which generates a specific tag for epigenetic transcriptional activation. It plays a role in the transcriptional activation of tumor suppressor p53 in response to DNA damage, as well as the transcription factor TAF10(Item No. 10228).{16846,17223} (R)-PFI-2 (Item No. 14678) is a potent, cell-permeable inhibitor of SET7/9 (IC50 = 2 nM) that demonstrates greater than 1,000-fold selectivity over a panel of 18 other methyltransferases.{26909} (S)-PFI-2, the inactive enantiomer, is 500-fold less potent (IC50 = 1 µM) and may serve as a negative control.{26909} See the Structural Genomics Consortium (SGC) website for more information.  

 

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Description

The inactive enantiomer of the SET7/9 inhibitor (R)-PFI-2 that may serve as a negative control

Formal name: 8-fluoro-1,2,3,4-tetrahydro-N-[(1S)-2-oxo-2-(1-pyrrolidinyl)-1-[[3-(trifluoromethyl)phenyl]methyl]ethyl]-6-isoquinolinesulfonamide, monohydrochloride

Synonyms:  (+)-PFI-2

Molecular weight: 536

CAS: 1627607-88-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Negative Controls||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Methylation

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