S-NEPC is a colorimetric substrate used to measure sEH activity. It also is a substrate for Glutathione S-transferase

S-NEPC – 25 mg

Brand:
Cayman
CAS:
147349-28-8
Storage:
-20
UN-No:
Non-Hazardous - /

Cytochrome P450 metabolites of arachidonic acid, such as 11(12)-EpETrE and 14(15)-EpETrE have been identified as endothelium derived hyperpolarizing factors with vasodilator activity.{12391} Soluble epoxide hydrolase (sEH) catalyzes the conversion of EpETrEs to the corresponding DiHETrEs thereby diminishing their activity.{14064} Inhibitors of sEH may therefore have clinical utility for treating hypertension and systemic inflammation.{14065,14072} S-NEPC is a colorimetric substrate used to measure sEH activity. It also is a substrate for Glutathione S-transferase, microsomal epoxide hydrolase and porcine liver carboxylesterase. Hydrolysis of S-NEPC by sEH yields 4-nitrophenol which can be quantified spectrophotometrically at 405 nm. S-NEPC is adaptable for use in 96-well microwell plate readers.  

 

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SKU: 10008609 - 25 mg Category:

Description

S-NEPC is a colorimetric substrate used to measure sEH activity. It also is a substrate for Glutathione S-transferase, microsomal epoxide hydrolase and porcine liver carboxylesterase. Hydrolysis of S-NEPC by sEH yields 4-nitrophenol which can be quantified spectrophotometrically at 405 nm. S-NEPC is adaptable for use in 96-well microwell plate readers.

Formal name: 4-nitrophenyl-2S,3S-epoxy-3 phenylpropyl carbonate

Synonyms: 

Molecular weight: 315.3

CAS: 147349-28-8

Purity: ≥98%

Formulation: A crystalline solid

Application|Enzyme Activity||Product Type|Biochemicals|Labeling & Detection|Dyes, Stains, & Indicators||Product Type|Biochemicals|Labeling & Detection|Enzyme Substrates||Research Area|Immunology & Inflammation||Research Area|Lipid Biochemistry|Cytochrome P450 Pathways

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